Metabolic disorders

FlorInScan

A balanced intestinal flora is essential for optimal health

FlorInScan

Laboratoires Réunis has many years of experience in the field of intestinal health and stool analysis. For nearly 17 years, we have been offering the FlorInScan extensive stool analysis. The individual profiles are continuously developed and adapted according to the latest scientific findings.

The following FlorInScan and other profiles are available at Laboratoires Réunis for targeted diagnostics and prevention:

FlorInScan includes the classical, quantitative, culture-based determination of fecal microflora (aerobic and anaerobic flora, fungi and yeasts), as well as the analysis of digestive performance by determining food residues,  the pH value and pancreatic elastase. An examination for occult blood in stool is also included. FlorInScan is an important component of preventive and personalized medicine for unclear gastrointestinal complaints or diseases of allergic or immunological origin.

FlorInScan Plus is an advanced screening: in addition to the determination of fecal microflora status, digestive performance and blood in stool, immunological and inflammatory markers (secretory IgA, calprotectin and alpha-1-antitrypsin) are included. These markers allow conclusions on invasive mucosal changes and permeability disorders, e.g. in the context of allergies and chronic inflammatory processes or tumors.

FlorInScan microbiome profile is our newly developed extensive profile based on molecular microbiome analysis. It includes the determination and quantification of health-related, anaerobic bacteria, which can only be detected by molecular genetic methods.

The FlorInScan microbiome profile ideally complements the classic, cultural-based FlorInScan analysis. The analysis of these relevant bacterial groups can additionally be included in the medical interpretation and prevention of chronic inflammatory bowel disease (IBD), irritable bowel syndrome, colon cancer and diabetes as well as in further therapy.

FlorVaScan

A multi-component analysis profile for the examination of the vaginal microflora

The vaginal flora is a complex ecosystem dominated mainly by lactobacilli sp.. In addition, a large variety of anaerobic, aerobic bacteria and Candida sp. occur as a transient accompanying flora with a low numbers of germs.

By producing lactic acid, lactobacilli keep the vaginal ecosystem in a slightly acidic pH range (3.8-4.5); additional antimicrobial substances such as H2O2 or bacteriocins keep the vaginal environment in a dynamic but sensitive balance.

A disturbed vaginal flora or a bacterial vaginosis, as well as recurrent infections carry an increased risk of ascending infections and are associated with the onset of prematurity and pregnancy complications. In addition, yeast colonization of the birth path is a common cause of 'diaper dermatitis' and 'oral thrush' in newborns. Women with recurrent vaginal complaints, vaginitis or repeated urinary tract infections should therefore be tested.

With FlorVaScan, Laboratoires Réunis offers you a comprehensive, multi-component analysis profile for the examination of the vaginal microflora. The following examinations are included in the test profile:

  • Quantification et identification microbiologique des levures et des lactobacilles (analyse par PCR et culture)
  • Microscopic examination of the vaginal exudate according to standardized criteria (Nugent Score) and determination of the degree of purity
  • Quantitative analysis of H2O2-producing lactobacilli
  • Quantitative analysis of the anaerobic and aerobic accompanying flora
  • Molecular biological detection of Trichomonas spp. and Gardnerella vaginalis, as well as the main causative agent of bacterial vaginosis
    (Atopobium vaginae, Mobiluncus spp.)
  • Quantification and microbiological identification of yeasts and lactobacilli (PCR analysis and culture)

FlorVaScan allows the doctor a targeted and therefore effective therapy. Through a detailed overall assessment of the vaginal flora, he can counteract an imbalance at an early stage and prevent the circulation of recurrent infections via specifying treatment recommendations.

BRAINgen

Preventive genetic test against Alzheimer's disease

Preventive genetic test against Alzheimer’s disease

The BRAINgen test analyzes genetic polymorphisms known to be involved in the development of Alzheimer’s disease as well as its possible underlying causes such as lipid metabolic disorders, inflammation processes and other independent disorders involved in other metabolic pathways.

BRAINgen allows to reduce the relative risk by preventive measures.

This test is carried out on a sub-contracted basis by an accredited laboratory.

OMEGA-3-SELECTgen (desaturase activity)

Analyse of variations in genes associated with utilization of fatty acids

Fatty acid nutrition and metabolism can influence inflammation risks. The test analyzes the variations in genes associated with utilization of fatty acids. The results can be used by doctors to recommend the optimal nutrition or supplementation in regard to omega3/6 fatty acid metabolism for the individual patient.

This test is carried out on a sub-contracted basis by an accredited laboratory.

OPTIMETgen

Methylation and detoxification efficiencies

OPTIMETgen is a panel of SNPs related to methylation and detoxification efficiencies. Based on the results, personalized recommendations are provided to optimize metabolic cycles of the methyl groups. These recommendations are also beneficial in the prevention of age-related diseases and aging.

This test is carried out on a sub-contracted basis by an accredited laboratory.

WEIGHTgen

Preventive genetic profile dedicated to weight control

Preventive genetic profile dedicated to weight control

Metabolic pathways and physiological parameters analyzed in this panel are related to adipogenesis, anthropometry, appetite control, energy expenditure, lipid metabolism and inflammation.

Personalized recommendations of WEIGHTgen can help manage and optimize weight conditions.

This test is carried out on a sub-contracted basis by an accredited laboratory.

HISTAMINgen

Identification of a primary histamine intolerance (HIT)

Genetic test for the identification of a primary histamine intolerance (HIT)

Histamine intolerance (HIT) is an imbalance in the histamine metabolism characterized by an increased supply of ingested or released histamine and an insufficient capacity of histamine degradation. HISTAMINgen analyzes the genetic predisposition for HIT.
In combination with the measurement of the activity of the histamine degrading enzyme diaminoxidase (DAO) and the evaluation of histamine levels, the results allow the differentiation between a primary and secondary histamine intolerance.
HISTAMINgen additionally evaluates the genetic penetrance for a reduced DAO-activity (HITscore).

This test is carried out on a sub-contracted basis by an accredited laboratory.

LIPIDgen

Preventive genetic test against atherosclerosis

Preventive genetic test against atherosclerosis

The test analyzes genetic polymorphisms known to be involved in the development of atherosclerosis as well as in its underlying causes such as lipid metabolic disorders. LIPIDgen is recommended to people with a family history of type III familial hypercholesterolemia or atherosclerosis, or if the patient presents very high levels of HDL, LDL or total cholesterol.

This test is carried out on a sub-contracted basis by an accredited laboratory.

DIABETOgen

Preventive genetic test against type II diabetes

Preventive genetic test against type II diabetes

The test analyzes polymorphisms involved in mechanisms linked to type II diabetes such as insulin and leptin sensitivity and other risk factors such as overweight.

DIABETOgen is indicated in case of family history of type II diabetes and/or metabolic syndrome.

This test is carried out on a sub-contracted basis by an accredited laboratory.

COELIAgen

Determination of the disease predisposition allele

Celiac disease

Also known as gluten-sensitive enteropathy, is an inflammatory autoimmune disorder in genetically predisposed patients (HLA-DQ2/DQ8 positive) that mainly affects the small intestine. With COELIAgen the celiac disease predisposition allele can be determined.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Gilbert‘s syndrome

Mild liver disorder linked to elevated levels of bilirubin

Gilbert‘s syndrome is a relative mild condition characterized by periods of elevated levels of bilirubin (hyperbilirubinemia). It is caused by changes in the UGT gene which are examined in this profile.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Additional tests

Along with these profiles, Laboratoires Réunis offers various examination methods

Laboratoires Réunis offers in addition to its profiles additional examination methods:

  • Urinary oestrogen metabolites
  • Lactobacilli
MTHFR methylentetrahydrofolate reductase

Increased homocysteine levels can increase the risk of thrombosis and atherosclerosis

Homocysteinemia

A thermolabile variant of the methylenetetrahydrofolate reductase, caused by a mutation at position 677, is associated with an increased homocysteine level. An increased homocysteine level can increase the risk of developing thrombosis and atherosclerosis.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Vitamins

To diagnose vitamin deficiencies

Vitamins are crucial parts of biochemical conversions in the body, such as co-factors in enzyme reactions and play an important role against oxidative stress. Deficiency or excess of vitamins can lead to a decreased function of several (organ) systems and the human body as a whole. Therefore, vitamin testing gives insight into absolute and relative deficiencies, and provides information about the impact of dietary changes and supplementations.

Laboratoires Réunis offers the following tests related to vitamins:

  • Vitamin B3
  • folic acid (vitamin B9)
  • Vitamin B12
  • Holotranscobalamin (active vitamin B12)
  • freeVitaminDgen (genetic test to determine the bio-availability of free vitamin D)
  • Biotin (vitamin H)
Minerals

To detect deficiencies across the mineral spectrum

Minerals are dissolved substances that are present within and outside the body cell. They are essential for several metabolic processes like enzyme activation, regulation of water balance and pH. Increased or decreased levels can impair metabolic processes and additionally give information about possible diseases.

Laboratoires Réunis offers complete analysis of minerals including sodium, potassium, magnesium, copper, iron, zinc, selenium. Single analysis on demand.

Profile short chain fatty acids

A balanced ratio of short-chain fatty acids is essential for intestinal health

Short-chain fatty acids are formed in the intestine during the metabolism of fibers and complex carbohydrates by bacteria. The fatty acids acetate, propionate and butyrate are particularly important: they are the main source of energy for the intestinal epithelium, stimulate the formation of mucus, have anti-inflammatory effects (mainly butyrate) and counteract weigh increase (mainly propionate).

A balanced ratio of short-chain fatty acids is thus essential for intestinal health. With the help of the profile for short-chain fatty acids, targeted nutritional measures as well as combinations with special probiotics can be taken.