Neurology

BRAINgen

Preventive genetic test against Alzheimer's disease

Preventive genetic test against Alzheimer’s disease

The BRAINgen test analyzes genetic polymorphisms known to be involved in the development of Alzheimer’s disease as well as its possible underlying causes such as lipid metabolic disorders, inflammation processes and other independent disorders involved in other metabolic pathways.

BRAINgen allows to reduce the relative risk by preventive measures.

This test is carried out on a sub-contracted basis by an accredited laboratory.

OPTIMETgen

Methylation and detoxification efficiencies

OPTIMETgen is a panel of SNPs related to methylation and detoxification efficiencies. Based on the results, personalized recommendations are provided to optimize metabolic cycles of the methyl groups. These recommendations are also beneficial in the prevention of age-related diseases and aging.

This test is carried out on a sub-contracted basis by an accredited laboratory.

EMOgen

Preventive genetic test against emotional instability

Preventive genetic test against emotional instability

EMOgen analyzes polymorphisms in relation with the metabolism of neurotransmitters (dopamine, serotonin), the homocysteine metabolism, serotonin synthesis and transport. This test allows to counteract the development of depression and anxiety disorders.

This test is carried out on a sub-contracted basis by an accredited laboratory.

DETOXgen micronutrition

Genes implied in phase I and phase II detoxification

DETOXgen micronutrition test is a preventive genetic profile for the determination of the phase I and phase II detoxification genes.

Micronutrition recommendations that are likely to have an impact on the genes and therefore on the enzymes function are widely detailed for each genetic variation.

This test is carried out on a sub-contracted basis by an accredited laboratory.

DETOXgen

Preventive genetic test for phase I & II detoxification

Preventive genetic test for phase I & II detoxification

This test analyzes key genes involved in xenobiotics and drug metabolism, e.g. detoxification of insecticides, herbicides, nicotine, alcohol and carcinogenic substrates. DETOXgen is especially appropriate as a basic profile for anti-aging treatment and allows to improve detoxification capacities in order to prevent environmental diseases.

This test is carried out on a sub-contracted basis by an accredited laboratory.

PHARMAgen Customized Analysis

Insight into pharmacogenetic and drug interactions

The PHARMAgen Customized Analysis enables physicians to gather relevant information about pharmacogenetic and drug interactions without it being necessary to know what drug pathways are involved. Three different approaches are possible, if the information is scientifically available:

  • the physician prescribes a PHARMAgen test for any drug and gets pharmacogenetic information,
  • the physician provides a list of drugs which a patient is already treated with and asks for drug interactions or possible pharmacogenetic issues, or finally
  • the physician may also prescribe the genetic analysis of known polymorphisms of any phase I enzyme.

This test is carried out on a sub-contracted basis by an accredited laboratory.

NEUROgen

Preventive genetic test against neurodegenerative diseases

Preventive genetic test against neurodegenerative diseases

NEUROgen analyzes polymorphisms involved in oxidative stress and detoxification processes, protein activity in relation with nervous system, all of them playing a role in the development of Alzheimer’s disease and Parkinson’s disease. It allows reducing the relative risk by preventive measures such as suitable dietary habits and/or lifestyle.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Lyme borreliosis

Lyme borreliosis is the most common bacterial disease in Europe transmitted by ticks. Depending on the region 5-35% of the ticks are infected. The clinical manifestations are multi-faceted; especially the chronic form with inflammation of the nervous system, the heart muscle and the joints is a therapeutic challenge. Efficient diagnostic tests are therefore essential for appropriate treatment measures.

The following tests are available at Laboratoires Réunis for targeted diagnostics and prevention:

  • Serology
  • ELIspot
  • Borrelia detection in ticks (PCR)
  • LTT (only available in Luxembourg)
Oxidative stress

Imbalance between antioxidants and free radicals

Oxidative stress

Oxygen is vital because it allows the production of energy from organic matter. Paradoxically, oxygen can also be harmful: physiological processes such as cellular respiration or protective mechanisms of the body constantly produce highly reactive oxygen compounds, including free radicals, all highly toxic.

Oxidative stress is defined as a disturbance in the balance between the production of free radicals and the ability of the body to neutralize them leading to an accumulation of free radicals. Oxidative stress over a long period may promote the development of diseases: cardiovascular diseases, chronic infectious diseases, inflammatory and neurodegenerative diseases and even cancer. Besides, oxidative stress plays also an important role in aging.

The factors or conditions below may contribute to oxidative stress:

  • Heavy physical efforts
  • Unbalanced diet
  • Consumption of tobacco and alcohol
  • Chronic fatigue
  • Physical or mental stress
  • Chronic and inflammatory diseases
  • Treatments such as chemotherapy, radiotherapy, oral contraception
  • Pollution, UV radiation
  • Infections

There is a conclusive link between high levels of oxidative stress and a patient’s health.
However, in more than 80% of cases, it is possible to reduce oxidative stress and thus to improve health status, regardless of clinical context or patient’s age.

Targeted laboratory diagnoses are therefore essential for an early diagnosis and treatment of oxidative stress.

Laboratoires Réunis offers, in addition to a wide range of individual analyses, the following laboratory diagnostic profiles for the detection of oxidative stress:

  • Oxidative stress-base profile: antioxidative capacity, oxidized LDL and 8-OHdG
  • Profile of complete oxidative stress: antioxidant capacity, 8-OHdG, oxidized LDL, SOD, GPX, Se, Zn, Vit A & E, ubiquinone, citrulline, nitrotyrosine,
  • Nitrosative stress profile: ubiquinone, nitrotyrosine, nitrophenylacetic acid, citrulline
MethylAge

Test if your lifestyle affects your metabolism

Actual Biological Age estimation 

  

Feeling old too soon? Test if your Lifestyle affects your metabolism. 

Epigenetics is a mechanism that allows to adapt gene expression to environmental factors. Your birthday gives a chronological age, some epigenetic biomarkers may give another biological one. This test will help change or reinforce good habits for a younger biological age. 

Neurotransmitters

An optimal neurotransmitter balance is necessary to maintain proper health

Neurotransmitters are chemical messengers used by the nervous system to relay information from one nerve to another. An optimal neurotransmitter balance is necessary to maintain proper health. Imbalances can cause the brain and the body to be over- or under-stimulated, producing neurological or psychological symptoms as anxiety, depression, chronic fatigue, insomnia or impulsivity.

At Laboratoires Réunis we offer the following neurotransmitters stress profiles:

  • Neurotransmitter stress profile basic (serotonin, dopamine, adrenaline, noradrenaline)
  • Neurotransmitter stress profile complete (catecholamines, glutamate, GABA, serotonin, creatinine)

These three neurotransmitter catabolites reflect the activity of neurotransmitters involved in cognitive functions and in the control of mood:

  • Vanillylmandelic acid
  • Homovanillic acid
  • 5-Hydroxyindoleacetic acid
Histamine Intolerance

Various targeted analyses to detect histamine intolerance

Laboratoires Réunis offers various  targeted examination methods for the detection of histamine intolerance:

  • Determination of DAO activity in serum
  • Determination of histamine concentration in stool
  • HISTAMINgen: genetic study of the DAO gene. This test determines if there is a genetic predisposition to histamine intolerance.