Gastroenterology

COELIAgen

Determination of the disease predisposition allele

Celiac disease

Also known as gluten-sensitive enteropathy, is an inflammatory autoimmune disorder in genetically predisposed patients (HLA-DQ2/DQ8 positive) that mainly affects the small intestine. With COELIAgen the celiac disease predisposition allele can be determined.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Crohn‘s disease

Susceptibility for Crohn's disease

Susceptibility for Crohn‘s disease

Several genes are associated with inflammatory bowel disease (IBD) susceptibility; most of them encode for proteins that regulate microbiota (NOD2) or that may control host response (IL-23R). A patient with NOD2 homozygosity carries a 20-fold increased risk for CD. In this profile SNPs in NOD2 and IL-23R genes are determined.

This test is carried out on a sub-contracted basis by an accredited laboratory.

DETOXgen

Preventive genetic test for phase I & II detoxification

Preventive genetic test for phase I & II detoxification

This test analyzes key genes involved in xenobiotics and drug metabolism, e.g. detoxification of insecticides, herbicides, nicotine, alcohol and carcinogenic substrates. DETOXgen is especially appropriate as a basic profile for anti-aging treatment and allows to improve detoxification capacities in order to prevent environmental diseases.

This test is carried out on a sub-contracted basis by an accredited laboratory.

DETOXgen micronutrition

Genes implied in phase I and phase II detoxification

DETOXgen micronutrition test is a preventive genetic profile for the determination of the phase I and phase II detoxification genes.

Micronutrition recommendations that are likely to have an impact on the genes and therefore on the enzymes function are widely detailed for each genetic variation.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Gilbert‘s syndrome

Mild liver disorder linked to elevated levels of bilirubin

Gilbert‘s syndrome is a relative mild condition characterized by periods of elevated levels of bilirubin (hyperbilirubinemia). It is caused by changes in the UGT gene which are examined in this profile.

This test is carried out on a sub-contracted basis by an accredited laboratory.

HISTAMINgen

Identification of a primary histamine intolerance (HIT)

Genetic test for the identification of a primary histamine intolerance (HIT)

Histamine intolerance (HIT) is an imbalance in the histamine metabolism characterized by an increased supply of ingested or released histamine and an insufficient capacity of histamine degradation. HISTAMINgen analyzes the genetic predisposition for HIT.
In combination with the measurement of the activity of the histamine degrading enzyme diaminoxidase (DAO) and the evaluation of histamine levels, the results allow the differentiation between a primary and secondary histamine intolerance.
HISTAMINgen additionally evaluates the genetic penetrance for a reduced DAO-activity (HITscore).

This test is carried out on a sub-contracted basis by an accredited laboratory.

LACTOgen

Primary lactose intolerance

Primary lactose intolerance

Lactose intolerance is caused by a lactase deficiency in the small bowel. Lactose cannot be hydrolyzed enzymatically into galactose and glucose and reaches the colon undigested. In the colon lactose binds water and provokes fermentation. These fermentation processes and the osmotic activity of undigested lactose cause the typical gastrointestinal symptoms.
With LACTOgen the genetic predisposition for a primary lactose intolerance is evaluated.

This test is carried out on a sub-contracted basis by an accredited laboratory.

LIPIDgen

Preventive genetic test against atherosclerosis

Preventive genetic test against atherosclerosis

The test analyzes genetic polymorphisms known to be involved in the development of atherosclerosis as well as in its underlying causes such as lipid metabolic disorders. LIPIDgen is recommended to people with a family history of type III familial hypercholesterolemia or atherosclerosis, or if the patient presents very high levels of HDL, LDL or total cholesterol.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Septin9-Test
Detection of colorectal cancer

Septin9 test: A simple blood test for the detection of colorectal cancer

Colorectal cancer (CRC) is the second most common cause of cancer-related deaths. Until now more than 230.000 people die of this disease within the european region. Although, CRC is curable if diagnosed early. A preventive screening on a regular basis is therefore of primordial importancel and should be an essential part of a general health check-up of people 50 years and older.

Concerning a preventive screening for CRC there is the possibility to regularly check the stool for occult blood. Furthermore, there is the possibility to carry out a colonoscopy that can be repeated after 10 years if the patient has been tested negative. Even though both screening methods have been proven to be very effective, the acceptance within the population is low. Reasons for the low acceptance are a dismissive attitude towards self-retrieved stool samples and towards colonoscopy. Therefore the Septin9-test offers a simple, non-invasive alternative for a preventive screening.

How does the test work?
In many diseases associated with tumors the methylation pattern of several genes can change. In colorectal cancer the Septin9 gene is methylated within a certain promotor region while it is not methylated in cells of the healthy intestinal mucosa.This methylated DNA can be detected by the Septin9 blood test. Only 1 blood draw is necessary.

How are the results of the Septin9 test interpreted?
A negative test result means that methylated Septin9-DNA could not be detected. So with this method, a  
CRC can be excluded. The negative predictive value of this test is 99,9%. That means that 999 of 1000 patients tested negative are correctly classified as being CRC negative (with an assumed CRC prevalence of 0,7%). A positive test result means that there is an increased likelihood for the presence of colorectal cancer. Since 45,7% of the patients tested positive are truly positve (positive predictive value) individuals with a positive test result are requested to undergo a colonoscopy for a definitive diagnosis.

WEIGHTgen

Preventive genetic profile dedicated to weight control

Preventive genetic profile dedicated to weight control

Metabolic pathways and physiological parameters analyzed in this panel are related to adipogenesis, anthropometry, appetite control, energy expenditure, lipid metabolism and inflammation.

Personalized recommendations of WEIGHTgen can help manage and optimize weight conditions.

This test is carried out on a sub-contracted basis by an accredited laboratory.

Oxidative stress

Imbalance between antioxidants and free radicals

Oxidative stress

Oxygen is vital because it allows the production of energy from organic matter. Paradoxically, oxygen can also be harmful: physiological processes such as cellular respiration or protective mechanisms of the body constantly produce highly reactive oxygen compounds, including free radicals, all highly toxic.

Oxidative stress is defined as a disturbance in the balance between the production of free radicals and the ability of the body to neutralize them leading to an accumulation of free radicals. Oxidative stress over a long period may promote the development of diseases: cardiovascular diseases, chronic infectious diseases, inflammatory and neurodegenerative diseases and even cancer. Besides, oxidative stress plays also an important role in aging.

The factors or conditions below may contribute to oxidative stress:

  • Heavy physical efforts
  • Unbalanced diet
  • Consumption of tobacco and alcohol
  • Chronic fatigue
  • Physical or mental stress
  • Chronic and inflammatory diseases
  • Treatments such as chemotherapy, radiotherapy, oral contraception
  • Pollution, UV radiation
  • Infections

There is a conclusive link between high levels of oxidative stress and a patient’s health.
However, in more than 80% of cases, it is possible to reduce oxidative stress and thus to improve health status, regardless of clinical context or patient’s age.

Targeted laboratory diagnoses are therefore essential for an early diagnosis and treatment of oxidative stress.

Laboratoires Réunis offers, in addition to a wide range of individual analyses, the following laboratory diagnostic profiles for the detection of oxidative stress:

  • Oxidative stress-base profile: antioxidative capacity, oxidized LDL and 8-OHdG
  • Profile of complete oxidative stress: antioxidant capacity, 8-OHdG, oxidized LDL, SOD, GPX, Se, Zn, Vit A & E, ubiquinone, citrulline, nitrotyrosine,
  • Nitrosative stress profile: ubiquinone, nitrotyrosine, nitrophenylacetic acid, citrulline
Profile short chain fatty acids

A balanced ratio of short-chain fatty acids is essential for intestinal health

Short-chain fatty acids are formed in the intestine during the metabolism of fibers and complex carbohydrates by bacteria. The fatty acids acetate, propionate and butyrate are particularly important: they are the main source of energy for the intestinal epithelium, stimulate the formation of mucus, have anti-inflammatory effects (mainly butyrate) and counteract weigh increase (mainly propionate).

A balanced ratio of short-chain fatty acids is thus essential for intestinal health. With the help of the profile for short-chain fatty acids, targeted nutritional measures as well as combinations with special probiotics can be taken.

COLOgen

Preventive genetic test against sporadic colorectal carcinoma

Preventive genetic test against sporadic colorectal carcinoma

Genetic polymorphisms analyzed in COLOgen target a pathway involved in cell growth, proliferation, differentiation and apoptosis. COLOgen should be prescribed to individuals with a family history of colorectal cancer or of intestinal polyps.

This test is carried out on a sub-contracted basis by an accredited laboratory.

FlorInScan

A balanced intestinal flora is essential for optimal health

FlorInScan

Laboratoires Réunis has many years of experience in the field of intestinal health and stool analysis. For nearly 17 years, we have been offering the FlorInScan extensive stool analysis. The individual profiles are continuously developed and adapted according to the latest scientific findings.

The following FlorInScan and other profiles are available at Laboratoires Réunis for targeted diagnostics and prevention:

FlorInScan includes the classical, quantitative, culture-based determination of fecal microflora (aerobic and anaerobic flora, fungi and yeasts), as well as the analysis of digestive performance by determining food residues,  the pH value and pancreatic elastase. An examination for occult blood in stool is also included. FlorInScan is an important component of preventive and personalized medicine for unclear gastrointestinal complaints or diseases of allergic or immunological origin.

FlorInScan Plus is an advanced screening: in addition to the determination of fecal microflora status, digestive performance and blood in stool, immunological and inflammatory markers (secretory IgA, calprotectin and alpha-1-antitrypsin) are included. These markers allow conclusions on invasive mucosal changes and permeability disorders, e.g. in the context of allergies and chronic inflammatory processes or tumors.

FlorInScan microbiome profile is our newly developed extensive profile based on molecular microbiome analysis. It includes the determination and quantification of health-related, anaerobic bacteria, which can only be detected by molecular genetic methods.

The FlorInScan microbiome profile ideally complements the classic, cultural-based FlorInScan analysis. The analysis of these relevant bacterial groups can additionally be included in the medical interpretation and prevention of chronic inflammatory bowel disease (IBD), irritable bowel syndrome, colon cancer and diabetes as well as in further therapy.

Histamine Intolerance

Various targeted analyses to detect histamine intolerance

Laboratoires Réunis offers various  targeted examination methods for the detection of histamine intolerance:

  • Determination of DAO activity in serum
  • Determination of histamine concentration in stool
  • HISTAMINgen: genetic study of the DAO gene. This test determines if there is a genetic predisposition to histamine intolerance.
Fructose Intolerance

Test for the detection of intestinal fructose intolerance

For the detection of intestinal fructose intolerance, Laboratoires Réunis offers the following analysis: Bacterial cleavage activity of fructose (as well as sorbitol) in stool.

For the detection of hereditary fructose intolerance, Laboratoires Réunis tests the most common mutations in the aldolase B gene with detailed interpretation of the results. Please ask for our genetic profile of hereditary fructose intolerance.

For further information please contact: sales@labo.lu oder +352 780 290-1

ImuPro

IgG food allergy testing and nutritional guidance

The ImuPro Concept - Diagnostics and unique post-test guidance

With an IgG food allergy (also called type III food allergy), the immune system reacts to usually harmless food allergens and produces specific antibodies, called IgG antibodies. These antibodies can then cause inflammatory reactions which may lead to various chronic complaints; the symptoms appear delayed up to three days after the consumption of a trigger food.

How does an IgG food allergy develop? Due to medicines, infections, mycosis, stress and environmental poisons, the integrity of the intestinal wall can be damaged and food components can slip between the intestinal cells. In some cases this triggers an immune response and the immune system starts to produce specific IgG antibodies against them.

ImuPro is a concept that combines a sophisticated and reliable blood analysis for IgG food allergies with unique post-test guidance. In an extensive laboratory analysis, high levels of IgG antibodies specific to particular food proteins are identified. The lab provides the doctor and patient with the test results and personal nutritional guidelines.

ImuPro is recommended in case of:

Bloating, constipation, irritable bowel syndrome (IBS), headache, migraine, obesity, depression, skin and joint problems.

ImuPro options:

· ImuPro Screen provides an individual analysis of 22 foods. It is a simple way to find out quickly whether an IgG food allergy might exist. It is a purely diagnostic examination and does not include any dietary recommendations.

· ImuPro Basic tests the 90 most important foods, such as typical kinds of meat, vegetables, fruits, cereals, dairy products and chicken egg. As well as a comprehensive report with accurate results at a glance, the documents will contain personal nutritional guidelines including individual recommendations.

· ImuPro Basic+ analyzes 180 foods. In addition to the typical most common vegetables, meat, fruits, cereals, dairy products and eggs, their alternatives and region-specific foods are also tested. The patients receives a comprehensive report with accurate results at the glance, nutritional guidelines including individual recommendations and a recipe book.

· ImuPro Complete tests 270 foods and additives (incl. the 90 foods in ImuPro Basic). In addition to the typical kinds of meat, vegetables, fruits, cereals, milk and egg, their alternatives and region-specific foods are also tested. Furthermore, a huge number of spices, tea, coffee, wine and also thickening agents and preservatives are examined. You will receive a comprehensive report with accurate results at a glance and personal nutritional guidelines which lead you through your change in diet. Your results pack also includes individual recommendations and a recipe book which is specifically tailored to your personal needs.

Neurotransmitters

An optimal neurotransmitter balance is necessary to maintain proper health

Neurotransmitters are chemical messengers used by the nervous system to relay information from one nerve to another. An optimal neurotransmitter balance is necessary to maintain proper health. Imbalances can cause the brain and the body to be over- or under-stimulated, producing neurological or psychological symptoms as anxiety, depression, chronic fatigue, insomnia or impulsivity.

At Laboratoires Réunis we offer the following neurotransmitters stress profiles:

  • Neurotransmitter stress profile basic (serotonin, dopamine, adrenaline, noradrenaline)
  • Neurotransmitter stress profile complete (catecholamines, glutamate, GABA, serotonin, creatinine)

These three neurotransmitter catabolites reflect the activity of neurotransmitters involved in cognitive functions and in the control of mood:

  • Vanillylmandelic acid
  • Homovanillic acid
  • 5-Hydroxyindoleacetic acid