Comprehensive analysis of the vaginal flora
The vaginal flora is an important, natural protective barrier against external pathogens. Lactobacilli represent the most important species of the vaginal flora. They acidify the vaginal milieu through the production of lactic acid. The acidic pH and antibacterial substances, like hydrogen peroxide and bacteriocins, protect the vaginal ecosystem against infections. In addition, a multiplicity of other aerobic and anaerobic microorganisms as well as fungal microbiota constitue, in low numbers, a further important part of the physiological vaginal flora.
Many external influences like stress, antibiotic intake or hormonal disorders can disturb the natural balance of the vaginal flora and may result in a dysbiosis. A vagnial dysbiosis may lead to a bacterial vaginosis with the risk of ascending infections. In such cases relapses are common; bacterial vaginosis represents also a risk factor for premature birth and complications during pregnancy.
FlorVaScan is intended for an overall assessment of the vaginal flora through a quantitative and semi-quantitative analysis of the symbiotic flora and of potential pathogenic germs. It includes also a microscopic examination of vaginalsecretions in accordance with standardized criteria (Nugent Score1) and an assignment to a level of purity2.
FlorVaScan includes also bacterial cultures and molecular biology examination of the accompanying anaerobic and aerobic flora and yeasts. Lactobacilli determination is carried out by bacterial culture and by molecularbiological techniques. Furthermore, with FlorVaScan the ability of lactobacilli to produce hydrogen peroxide is analysed.The most important main bacteria of a vaginosis (Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp.) are detected through PCR testing. If necessary, a targeted therapy recommendation is established (antibiogram).
FlorVaScan is aimed for women with recurrent vaginal discomfort and furthermore, to monitor treatment success. Furthermore, FlorVaScan can be included in prenatal care as well as before gynecological surgery or insertion of a pessary. FlorVaScan can also be an option for women with an unfulfilled wish for children or before an assisted reproduction.
(1) Nugent, R.P., Krohn, M.A., & Hillier, S.L. (1991). Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol, 29
(2), 297-301. (2) Ison CA, Hay PE (2002) Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics. Sex Transm Infect. Dec; 78(6):415-5.